Basophil sensitivity through CD63 or CD203c is a functional measure for specific immunotherapy

Table 1 Selected salient clinical data for each patient

Pt nr	Treatment	Side effects	maintenance dose	Ratio CD63 activation at 0,1/1
1	Traditional	fatigue	40000	1,07
2	traditional	weals	100000	1,05
3	traditional	weals	100000	0,82
4	traditional	weals, fatigue	100000	0,87
5	traditional, discontinued	heartbeat, nervousness	(20)	0,78
6	cluster, discontinued	itchy tongue	(1000)	0,78
7	cluster	hyperventilation	100000	0,65
8	cluster	none	100000	0,95
9	cluster	none	100000	0,66
10	cluster	weals, itch, fatigue	100000	0,91
11	cluster	weals	100000	0,87
12	cluster	none	100000	0,71
13	cluster	weals	60000	0,51
14	cluster	weals	100000	1,22
15	cluster	weals, fatigue	100000	1,00
16	change	weals, oedema	100000	0,66
17	change	weals, fatigue	100000	0,59
18	change	weals	100000	2,09
19	change	weals	100000	1,36
20	change	weals	100000	1,13

Side effects, maintenance dose and CD63 activation at 0,1 ug/ml venom/1 ug/ml venom are listed against SCIT regimen (traditional 16 week up-dosing protocol/7 week cluster up dosing protocol/change from 7 week to 16 week protocol) applied. Where the ratio of activation exceeds 0,95 it has been shown to be predictive of side effects [7] and is printed bold. Side effects were weals around the site of injection

ISSN: 1476-7961