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Table 1 Genotype distributions and allele frequencies of four HNMT polymorphisms and one ABP1 polymorphism for asthmatic patients versus control group (figures in parentheses indicate percentages)

From: Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control study

Gene Polymorphism Asthma Control P value
  1637    N = 139 N = 137 0.352
   genotypes TT 38 (27.3) 41 (29.9)  
    CT 75 (53.9) 79 (57.7)  
    CC 26 (18.8) 17 (12.4)  
   alelles T 151 (54.3) 161 (58.7) 0.303
    C 127 (45.7) 113 (41.3)  
  314    N = 149 N = 147 0.042*
   genotypes CC 99 (66.4) 119 (80.9)  
    CT 43 (28.9) 26 (17.7)  
    TT 7 (4.7) 2 (1.4)  
   alelles C 241 (80.9) 264 (89.8) 0.048*
    T 45 (19.1) 30 (10.2)  
HNMT 411    N = 146 N = 156 0.720
   genotypes TT 7 (4.8) 5 (3.2)  
    CT 43 (29.4) 50 (32.1)  
    CC 96 (65.8) 101 (64.7)  
   alelles T 57 (19.5) 60 (19.2) 1.000
    C 235 (80.5) 252 (80.8)  
  1097    N = 146 N = 156 0.977
   genotypes CC 90 (61.6) 95 (60.9)  
    CG 51 (34.9) 55 (35.3)  
    GG 5 (3.4) 6 (3.8)  
   alelles C 231 (79.1) 245 (78.5) 0.920
    G 61 (20.9) 67 (21.5)  
ABP1 His645Asp    N = 146 N = 156 0.530
   genotypes TT 75 (51.4) 79 (54.1)  
    AT 52 (35.6) 54 (37.0)  
    AA 19 (13.0) 13 (8.9)  
   alelles T 202 (69.2) 212 (72.6) 0.412
    A 90 (30.8) 80 (27.4)  
  1. * indicates significance: χ2 = 6.302, df = 2