Table 1 Genotype distributions and allele frequencies of four HNMT polymorphisms and one ABP1 polymorphism for asthmatic patients versus control group (figures in parentheses indicate percentages)
Gene | Polymorphism | Asthma | Control | P value | ||
|---|---|---|---|---|---|---|
1637 | N = 139 | N = 137 | 0.352 | |||
genotypes | TT | 38 (27.3) | 41 (29.9) | |||
CT | 75 (53.9) | 79 (57.7) | ||||
CC | 26 (18.8) | 17 (12.4) | ||||
alelles | T | 151 (54.3) | 161 (58.7) | 0.303 | ||
C | 127 (45.7) | 113 (41.3) | ||||
314 | N = 149 | N = 147 | 0.042* | |||
genotypes | CC | 99 (66.4) | 119 (80.9) | |||
CT | 43 (28.9) | 26 (17.7) | ||||
TT | 7 (4.7) | 2 (1.4) | ||||
alelles | C | 241 (80.9) | 264 (89.8) | 0.048* | ||
T | 45 (19.1) | 30 (10.2) | ||||
HNMT | 411 | N = 146 | N = 156 | 0.720 | ||
genotypes | TT | 7 (4.8) | 5 (3.2) | |||
CT | 43 (29.4) | 50 (32.1) | ||||
CC | 96 (65.8) | 101 (64.7) | ||||
alelles | T | 57 (19.5) | 60 (19.2) | 1.000 | ||
C | 235 (80.5) | 252 (80.8) | ||||
1097 | N = 146 | N = 156 | 0.977 | |||
genotypes | CC | 90 (61.6) | 95 (60.9) | |||
CG | 51 (34.9) | 55 (35.3) | ||||
GG | 5 (3.4) | 6 (3.8) | ||||
alelles | C | 231 (79.1) | 245 (78.5) | 0.920 | ||
G | 61 (20.9) | 67 (21.5) | ||||
ABP1 | His645Asp | N = 146 | N = 156 | 0.530 | ||
genotypes | TT | 75 (51.4) | 79 (54.1) | |||
AT | 52 (35.6) | 54 (37.0) | ||||
AA | 19 (13.0) | 13 (8.9) | ||||
alelles | T | 202 (69.2) | 212 (72.6) | 0.412 | ||
A | 90 (30.8) | 80 (27.4) | ||||