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Table 2 Cytokines in supernatants of cultured spleen cells from mice treated with AndoSan™ or PBS p.o. before or after sensitization against OVA s.c..

From: An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy

Cytokine Pre-OVA treatment Post-OVA treatment
  AndoSan™/PBS index AndoSan™/PBS index
IFNγ 1.13* ± 0.06 0.90* ± 0.11
IL-2 1.06*, ** ± 0.13 1.07 ± 0.00
IL-4 0.95 ± 0.15 0.82* ± 0.10
IL-5 0.83 ± 0.08 0.78 ± 0.05
IL-10 0.88* ± 0.08 0.89 ± 0.01
  1. The indices are given as mean ± s.e.m. of 2–5 experiments in duplicates, each comprising 8 mice per group, of the highest read-out data of either OVA or Con A stimulated cultures for either 48 h or 72 h is given for each experiment. *In one of the experiments cytokine levels in supernatants of cell cultures from AndoSan™ treated mice were lower than from PBS treated mice (p < 0.05). **In one of the experiments cytokine levels in supernatants of cell cultures from AndoSan™ treated mice were higher than from PBS treated mice (p < 0.05). All over, indices for Th2 cytokines were lower than indices for Th1 cytokines (p = 0.026). The lack of data from some experiments is due to values below detection limit of assay.