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Table 4 Family-based Analysis of Association between IL12A and Asthma, Total IgE, and STR to Dust Mite among Children with Asthma in Costa Rica and CAMP

From: Polymorphisms in IL12A and cockroach allergy in children with asthma

SNP (dbSNP rs number) Chromosome 3 position Alleles Location Costa Ricans Whites
     N* Model FBAT p-value N* Model FBAT p-value
Asthma          
rs2243123 161192344 T>C Intron 245 a 0.86 301 a 0.58
rs2243151 161198714 A>T 3'UTR 277 a 0.46 335 a 0.49
rs668998 161198244 A>G 3'UTR 282 a 0.96 337 a 0.36
rs17826053 161200322 T>G 3'UTR 121 a 0.42 203 a 0.14
Total IgE          
rs2243123 161192344 T>C Intron 245 a 0.30 301 a 0.54
rs2243151 161198714 A>T 3'UTR 277 a 0.41 335 a 0.60
rs668998 161198244 A>G 3'UTR 282 a 0.32 337 a 0.47
rs17826053 161200322 T>G 3'UTR 121 a 0.61 203 a 0.19
Positive IgE to D. pteronyssinus          
rs2243123 161192344 T>C Intron 245 a 0.30    
rs2243151 161198714 A>T 3'UTR 277 a 0.43    
rs668998 161198244 A>G 3'UTR 282 a 0.67    
rs17826053 161200322 T>G 3'UTR 121 a 0.60    
STR to D. pteronyssinus          
rs2243123 161192344 T>C Intron 244 a 0.95 301 a 0.21
rs2243151 161198714 A>T 3'UTR 276 a 0.77 335 a 0.18
rs668998 161198244 A>G 3'UTR 280 a 0.52 337 a 0.10
rs17826053 161200322 T>G 3'UTR 120 a 0.43 203 a 0.85
  1. *Number of informative families
  2. In Costa Rica, a positive IgE to D. pteronyssinus was defined as a value >= 0.35 IU/ml.
  3. Allergen-specific IgE was not measured in CAMP.