Polymorphisms in IL12A and cockroach allergy in children with asthma

Table 4 Family-based Analysis of Association between IL12A and Asthma, Total IgE, and STR to Dust Mite among Children with Asthma in Costa Rica and CAMP

SNP (dbSNP rs number)	Chromosome 3 position	Alleles	Location	Costa Ricans			Whites
				N*	Model	FBAT p-value	N*	Model	FBAT p-value
Asthma
rs2243123	161192344	T>C	Intron	245	a	0.86	301	a	0.58
rs2243151	161198714	A>T	3'UTR	277	a	0.46	335	a	0.49
rs668998	161198244	A>G	3'UTR	282	a	0.96	337	a	0.36
rs17826053	161200322	T>G	3'UTR	121	a	0.42	203	a	0.14
Total IgE
rs2243123	161192344	T>C	Intron	245	a	0.30	301	a	0.54
rs2243151	161198714	A>T	3'UTR	277	a	0.41	335	a	0.60
rs668998	161198244	A>G	3'UTR	282	a	0.32	337	a	0.47
rs17826053	161200322	T>G	3'UTR	121	a	0.61	203	a	0.19
Positive IgE to *D. pteronyssinus*
rs2243123	161192344	T>C	Intron	245	a	0.30
rs2243151	161198714	A>T	3'UTR	277	a	0.43
rs668998	161198244	A>G	3'UTR	282	a	0.67
rs17826053	161200322	T>G	3'UTR	121	a	0.60
STR to *D. pteronyssinus*
rs2243123	161192344	T>C	Intron	244	a	0.95	301	a	0.21
rs2243151	161198714	A>T	3'UTR	276	a	0.77	335	a	0.18
rs668998	161198244	A>G	3'UTR	280	a	0.52	337	a	0.10
rs17826053	161200322	T>G	3'UTR	120	a	0.43	203	a	0.85

*Number of informative families
In Costa Rica, a positive IgE to D. pteronyssinus was defined as a value >= 0.35 IU/ml.
Allergen-specific IgE was not measured in CAMP.

ISSN: 1476-7961