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Table 3 Family-based Analysis of Association between IL12A and Cockroach Sensitization among Children with Asthma in Costa Rica and White Children with Asthma in CAMP

From: Polymorphisms in IL12A and cockroach allergy in children with asthma

     Costa Ricans CAMP
SNP (dbSNP number) Chromosome 3 position Alleles Location N* Model FBAT P value N* Model FBAT P value
Positive IgE to B. germanica          
rs2243123 161192344 T>C Intron 245 a +0.046    
rs2243151 161198714 A>T 3'UTR 277 a 0.05    
     133 r +0.04    
STR to P. Americana          
rs2243123 161192344 T>C Intron 244 a +0.03 301 a -
     84 r +0.002 94 r -
rs2243151 161198714 A>T 3'UTR 276 a +0.03 335 a -
     133 r +0.01 169 r -
rs17826053 161200322 T>G 3'UTR 120 a - 203 a +0.02
     119 r - 198 r +0.01
STR to B. germanica          
rs2243123 161192344 T>C Intron 244 a - 301 a -
     84 r +0.01 94 r 0.09
rs2243151 161198714 A>T 3'UTR 276 a 0.08 335 a 0.09
     133 r +0.0007 169 r -0.03
rs17826053 161200322 T>G 3'UTR 120 a - 203 a +0.004
     119 r - 198 r +0.007
  1. *Number of informative families.
  2. STR = skin test reactivity.
  3. + and - signs preceding significant P values indicate the direction of the observed associations.
  4. In Costa Rica, a positive IgE to B. germanica was defined as a value >= 0.35 IU/ml. Allergen-specific IgE was not measured in CAMP.
  5. 3' UTR = 3' untranslated region.
  6. For ease of exposition, only p values < 0.1 are displayed. A dash "-" has been used to represent p values ≥ 0.1.