Figure 3

Omalizumab targets the Cε3 epitope on the fragment of IgE which binds the α chain of the high-affinity trimeric IgE receptor, thus blocking the binding of IgE with its receptor. On the left, formation of a hexamer complex of omalizumab-IgE is shown, and on the right molecular sizes of the IgE and Omalizumab molecules are shown.