Figure 1From: CpG Immunotherapy in Chenopodium album sensitized mice: The comparison of IFN-gamma, IL-10 and IgE responses in intranasal and subcutaneous administrationsThe comparison of cytokines and antibody levels. The mean values of systemic and local concentrations of cytokines and IgE antibody measured by ELISA in S.C and I.N CpG/Ch.a treated asthmatic mice in comparison with Ch.a, PBS and ODN treated controls. (a): IFN-γ produced by splenocytes in CpG/Ch.a treated mice are increased in both routes of administrations, (b): IL-10 induced by splenocytes suppressed in S.C and enhanced in I.N routes, (c and d): IFN-γ and IL-10 in BAL fluids are equally increased in both S.C and I.N treated mice with CpG/Ch.a. (e): total serum IgE decreased in mice treated with CpG/Ch.a through I.N or S.C routes. P values in all analysis are as ≤ 0.01.Back to article page