The comparison of cytokines and antibody levels. The mean values of systemic and local concentrations of cytokines and IgE antibody measured by ELISA in S.C and I.N CpG/Ch.a treated asthmatic mice in comparison with Ch.a, PBS and ODN treated controls. (a): IFN-γ produced by splenocytes in CpG/Ch.a treated mice are increased in both routes of administrations, (b): IL-10 induced by splenocytes suppressed in S.C and enhanced in I.N routes, (c and d): IFN-γ and IL-10 in BAL fluids are equally increased in both S.C and I.N treated mice with CpG/Ch.a. (e): total serum IgE decreased in mice treated with CpG/Ch.a through I.N or S.C routes. P values in all analysis are as ≤ 0.01.