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Table 6 Mean adjusted1) total serum IgE levels in cases and non-atopic controls2) in dependence of IL6(-174G>C) or IL18(-137G>C) genotype in the SAPALDIA Cohort Study.

From: Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA)

   Hay fever3) Controls2)
Genotype   Number Mean 4) P-value Number Mean 4) P-value
IL6 (-174G>C) GG 347 83.56   986 25.49  
  GC 483 61.29   1255 22.35  
  CC 148 62.26 0.009 412 23.29 0.11
IL18 (-137G>C) GG 494 71.85   1464 23.79  
  GC 419 60.73   997 23.21  
  CC 71 103.20 0.01 196 24.96 0.80
  1. 1) Adjusted for age and gender. 2) Non-atopic controls were free of self-reported hay fever, self-reported eczema and physician-diagnosed asthma. 3) Self-reported hay fever cases answered yes to 'Have you ever had a problem with sneezing or a runny nose or a blocked nose when you did not have a cold?', irrespective of self-reported asthma or eczema. 4) Measured total serum IgE levels were log-transformed and adjusted means are geometric means.