Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA)

Table 5 Adjusted¹⁾ association of IL6(-174G>C) and IL18(-137G>C) with elevated total IgE levels²⁾ and allergen sensitization³⁾in the SAPALDIA Cohort Study.

		Elevated total IgE				Allergen sensitization (Phadiatop)
Genotype		cases/controls ⁴⁾	Odds Ratio	95% Confidence Interval	P-value	cases/controls ⁴⁾	Odds Ratio	95% Confidence Interval	P-value
IL6(-174G>C)	GG	462/804	1		--	596/1445	1		--
	GC	515/1078	0.83	0.71 – 0.97	0.02	768/1873	1	0.88 – 1.13	0.97
	CC	187/348	0.94	0.76 – 1.16	0.54	250/618	0.99	0.83 – 1.18	0.95
IL18(-137G>C)	GG	631/1237	1		--	860/2167	1		--
	GC	447/831	1.07	0.92 – 1.24	0.40	635/1504	1.1	0.95 – 1.21	0.26
	CC	90/164	1.07	0.82 – 1.41	0.61	125/275	1.1	0.91 – 1.43	0.27

1) Adjusted for age and gender. ²⁾ Elevated total IgE cases had serum levels of total IgE >100 kU/L, measured by CAP system (Pharmacia Diagnostics). ³⁾ Allergen sensitization cases had at least one positive allergen specific signal, measured by Phadiatop test using CAP FEIA system (Pharmacia Diagnostics). ⁴⁾ Controls had total IgE ≤ 100 kU/L or were negative for all specific allergen tested (Phadiatop).

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