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Table 4 Adjusted1) association of IL6(-174G>C) and IL18(-137G>C) with hay fever2) in the SAPALDIA Cohort Study.

From: Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA)

  

Hay fever

Genotype

 

cases/controls 3)

Odds Ratio

95% Confidence Interval

P-value

IL6(-174G>C)

GG

393/1112

1

 

--

 

GC

537/1386

1.1

0.95 – 1.29

0.21

 

CC

169/451

1.04

0.84 – 1.28

0.74

IL18(-137G>C)

GG

555/1619

1

 

--

 

GC

468/1117

1.24

1.07 – 1.43

0.004

 

CC

82/217

1.08

0.82 – 1.42

0.60

  1. 1) Adjusted for age and gender. 2) Self-reported hay fever cases answered yes to 'Have you ever had a problem with sneezing or a runny nose or a blocked nose when you did not have a cold?', irrespective of self-reported asthma or eczema. 3) Non-atopic controls were free of self-reported hay fever, self-reported eczema and physician-diagnosed asthma. 4) Controls had total IgE ≤ 100 kU/L or were negative for all specific allergen tested (Phadiatop).
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Clinical and Molecular Allergy

ISSN: 1476-7961

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