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Table 4 Adjusted1) association of IL6(-174G>C) and IL18(-137G>C) with hay fever2) in the SAPALDIA Cohort Study.

From: Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA)

   Hay fever
Genotype   cases/controls 3) Odds Ratio 95% Confidence Interval P-value
IL6(-174G>C) GG 393/1112 1   --
  GC 537/1386 1.1 0.95 – 1.29 0.21
  CC 169/451 1.04 0.84 – 1.28 0.74
IL18(-137G>C) GG 555/1619 1   --
  GC 468/1117 1.24 1.07 – 1.43 0.004
  CC 82/217 1.08 0.82 – 1.42 0.60
  1. 1) Adjusted for age and gender. 2) Self-reported hay fever cases answered yes to 'Have you ever had a problem with sneezing or a runny nose or a blocked nose when you did not have a cold?', irrespective of self-reported asthma or eczema. 3) Non-atopic controls were free of self-reported hay fever, self-reported eczema and physician-diagnosed asthma. 4) Controls had total IgE ≤ 100 kU/L or were negative for all specific allergen tested (Phadiatop).