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Table 1 Characteristics1) of the study populations and genotype distribution.

From: Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA)

  ECRHS-Basel N = 418 (%) SAPALDIA N = 6003 (%)
Female proportion 211 (50.5) 3022 (50.3)
Age [years] 43.4 (± 7.0) 41.3 (± 11.4)
Age range [years] 29.3 to 55.1 18.2 to 61.8
Hay fever cases2) 192 (45.9) 1105 (18.4)
Asthma cases3) 78 (18.2) 369 (6.2)
Eczema cases4) 200 (47.9) 2383 (39.7)
Elevated total IgE cases5) 101 (24.9) 1168 (21.6)
Allergen sensitization cases6) 178 (42.6) 1620 (29.1)
Non-atopic controls7) 125 (29.9) 2953 (49.2)
  1. 1) Presented in N (%) for categorical and in mean (± SD) for continuous variables.
  2. 2) Self-reported hay fever cases answered yes to, Have you ever had a problem with sneezing or a runny nose or a blocked nose when you did not have a cold?', irrespective of self-reported asthma or eczema.
  3. 3) Physician-diagnosed asthma cases answered twice yes to 'Have you ever had asthma? Was this confirmed by a doctor?', irrespective of self-reported hay fever or eczema.
  4. 4) Self-reported eczema cases answered yes to 'Have you ever had eczema or any other kind of skin allergy?', irrespective of self-reported asthma or hay fever.
  5. 5) Elevated total IgE cases had serum total IgE level >100 kU/L, measured by CAP system (Pharmacia)
  6. 6) Allergen sensitization cases had at least one allergen specific IgE >0.35 kU/L, measured by CAP system (Pharmacia) for ECRHS-BS and by Phadiatop test (CAP FEIA system, Pharmacia) for SAPALDIA.
  7. 7) Non-atopic controls were free of self-reported hay fever, self-reported eczema and physician-diagnosed asthma.