SEB was evaluated with ELISA in the sinus wash fluids. Bars represent levels of SEB as mean ± SD. *, p < 0.05, compared with healthy controls. #, p < 0.05, compared with the second time within the same group. 1st: samples are collected before the functional endoscope sinus surgery (FESS). 2nd: samples are collected 2 months after the FESS. Healthy: healthy controls. CRS: patients with chronic rhinosinusitis. Asthma: patients with asthma. CRS-asthma: patients with both CRS and asthma.