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Figure 2 | Clinical and Molecular Allergy

Figure 2

From: House dust mite major allergens Der p 1 and Der p 5 activate human airway-derived epithelial cells by protease-dependent and protease-independent mechanisms

Figure 2

Effects of the cysteine protease inhibitor E64 (10 μM) on IL-6 (open bars) and IL-8 (hatched bars) protein secretion. A549 cells were stimulated during 24 hours with an optimal concentration of recombinant allergens: Der p 1 (20 μg/ml), Der p 5 (20 μg/ml) or a combination of Der p1 plus Der p 5. IL-6 protein levels are expressed as pg/ml, whereas IL-8 protein levels are expressed as ng/ml. * p < 0.05, significantly enhanced expression compared to negative control (medium); # p < 0.05, significantly diminished expression compared to Der p 1-induced levels; $ p < 0.05, significantly diminished expression compared to Der p1 plus Der p5-induced levels.

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Clinical and Molecular Allergy

ISSN: 1476-7961

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