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Table 2 IL-4Rα single nucleotide polymorphisms in asthmatic and cystic fibrosis patients with allergic bronchopulmonary aspergillosis (ABPA).

From: IL-4 alpha chain receptor (IL-4Rα) polymorphisms in allergic bronchopulmonary sspergillosis

Study Number of Patients P*
  ABPA (40) Non-ABPA (56)  
Extracellular IL-4Rα SNPs    
   ile75val 32 (80%) 30 (54%) 0.008
   asn98thr 2 (5%) 4 (8%) ns
   Homozygous ile75val 17 (43%) 6 (11%) 0.0003
Cytoplasmic IL-4Rα SNPs    
   glu400ala 5 (13%) 3 (5%) ns
   cys431arg 3 (8%) 4 (7%) ns
   ser503pro 9 (23%) 10 (18%) ns
   gln576arg 8 (20%) 14 (25%) ns
Any IL-4Rα SNP 38 (95%) 34 (61%) 0.0001
Extracellular and Cytoplasmic IL-4Rα SNP 11 (28%) 12 (21%) ns
  1. Abbreviations: IL-4Rα, interleukin 4 receptor alpha chain; SNP, single nucleotide polymorphism; ABPA, allergic bronchopulmonary aspergillosis; ns, not significant.
  2. In parentheses, percentage (%) of patients.
  3. * Chi square analysis comparing ABPA versus Non-ABPA patients.