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Table 3 Distribution of combinations of -33C>TIL4 and 576Q>RIL4RA SNPs

From: Interleukin-4 (IL4) and Interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control study

Genetic Variants

CTR

Asthma

Atopy

AA

PA

Monte Carlo p value (after 104 simulations)

      

CTR vs Asthma

CTR vs Atopy

CTR vs AA

CTR vs PA†

CQ

0.73

0.71

0.72

0.73

0.68

0.584

0.813

0.900

0.281

CR

0.18

0.14

0.12

0.11

0.14

0.334

0.184

0.092

0.425

TQ

0.05

0.12

0.13

0.13

0.16

0.013*

0.016**

0.017***

0.002‡

TR

0.04

0.03

0.03

0.03

0.02

0.395

0.392

0.786

0.492

  1. CTR, Controls; AA, Allergic Asthma; PA, Persistent Asthma
  2. * Odds ratio: 2.59 95% CI: 1.18–5.66
  3. ** Odds ratio: 2.65 95% CI: 1.19–5.87
  4. *** Odds ratio: 2.62 95% CI: 1.17–5.90
  5. †Global distribution of genetic variants: Fisher's p value = 0.018, Monte Carlo p value (after 104 simulations) = 0.017
  6. ‡ Odds ratio: 3.39 95% CI: 1.50–7.66