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Figure 7 | Clinical and Molecular Allergy

Figure 7

From: The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression

Figure 7

The human IL-5 promoter (0 to -1054) contains a putative retinoic acid response element (RARE). A RARE contains two RARE ½ sites [G(T/G)TCA] and from 1 to 5 spacer nucleotides designated by the “DR” designation. (A) A Schematic representation of the IL-5 locus between species. The putative RARE location in the IL5p is compared between human, mouse, rat, and rhesus. Alignment of DNA sequence around the IL5p putative RARE between (B) human and rhesus, and (C) mouse and rat.

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Clinical and Molecular Allergy

ISSN: 1476-7961

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