Inhaled corticosteroid use is associated with increased circulating T regulatory cells in children with asthma

Table 4 Increased Treg Cell Frequency is Associated with ICS Use and Not Asthma Status

Patient Classification	n	%Treg cells/CD4+ cells (mean, adjusted)	effect*	95%CI	p-value
Children not on ICS	118	6.30	--	--	0.005
Children treated with ICS	39	7.55	1.26	(0.40, 2.12)	0.005
No asthma	93	7.03	--	--	0.68
Non-atopic asthma	20	7.05	0.02	(-0.80, 0.84)
Atopic asthma	44	6.69	-0.34	(-1.18, 0.50)
Interaction: P = 0.35

ICS Inhaled corticosteroid, 95% CI, 95% confidence interval.
*difference in LS means%Treg cells/CD4+ cells between the groups. Two asthma subjects are missing FEIA data and were excluded from the analysis.

ISSN: 1476-7961