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Table 2 Increased Treg cell frequency is associated with ICS use and not asthma disease Severity

From: Inhaled corticosteroid use is associated with increased circulating T regulatory cells in children with asthma

Patient Classification

n

% Treg cells/CD4+ cells (mean, adjusted)

effect*

95%CI

p- value

Children not on ICS

119

6.32

--

--

0.02

Children treated with ICS

40

7.37

1.06

(0.15, 1.96)

No asthma

93

6.93

--

--

0.96

Intermittent

31

6.77

-0.17

(-0.91, 0.57)

Mild persistent

15

6.77

-0.17

(-1.15, 0.82)

Mod/Sev persistent

20

6.91

-0.02

(-1.17, 1.12)

Interaction: P = 0.78

  1. ICS Inhaled corticosteroid, 95% CI, 95% confidence interval.
  2. *differences in least squares (LS) means in%Treg cells/CD4+ cells between the groups.