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Table 1 Characteristics of study subjects

From: Inhaled corticosteroid use is associated with increased circulating T regulatory cells in children with asthma

Disease classification

No asthma

Intermittent

Mild persistent

Moderate/severe persistent

p value

Number of subjects

93

31

15

20

 

Age(years) (±SD)

7.6 ± 0.8

7.6 ± 0.5

7.4 ± 0.8

7.4 ± 1.0

0.54

Female

46 (49%)

10 (32%)

6 (40%)

8 (40%)

0.38

Male

47 (51%)

21 (68%)

9 (60%)

12 (60%)

 

Caucasian

89 (96%)

29 (94%)

11 (73%)

16 (80)

0.008

African American

3 (3%)

3 (10%)

6 (40%)

6 (30%)

<0.0001

American Indian

4 (4%)

0 (0%)

0 (0%)

0 (0%)

0.84

Asian

0 (0%)

1 (3%)

0 (0%)

0 (0%)

0.42

Hispanic or Latino

4 (4 %)

1 (3%)

1 (7%)

0 (0%)

0.83

Spirometry(median [25th, 75th])

     

FEV1

1.50 [1.37, 1.72]

1.54 [1.27, 1.66]

1.23 [1.09, 1.63]

1.46 [1.29, 1.83]

0.11

FEV1% pred

103 [95, 109]

103 [89, 113]

90 [85, 101]

102 [94, 107]

0.43

FVC

1.85 [1.64, 2.06]

1.81 [1.60, 2.05]

1.62 [1.31, 1.93]

1.88 [1.51, 2.21]

0.06

FVC% pred

108 [100, 115]

110 [98, 118]

96 [94, 116]

114 [105, 120]

0.19

FEV0.5

1.11 [1.01, 1.30]

1.14 [0.97, 1.29]

0.92 [0.78, 1.18]

1.07 [0.97, 1.21]

0.07

FEF25-75

1.63 [1.23, 1.95]

1.54 [1.03, 1.88]

1.21 [0.98, 1.51]

1.48 [1.25, 1.70]

0.16

PEF

2.98 [2.58, 3.50]

3.20 [2.59, 3.65]

2.46 [2.16, 2.99]

2.66 [2.51, 3.17]

0.07

FEV1/FVC

0.85 [0.79, 0.88]

0.82 [0.77, 0.86]

0.82 [0.81, 0.88]

0.81 [0.77, 0.86]

0.43

FEV0.5/FVC

0.63 [0.58, 0.69]

0.60 [0.55, 0.65]

0.62 [0.56, 0.65]

0.57 [0.55, 0.65]

0.24

Total lgE (median [25th, 75th])

38 [19, 92]

49 [15, 103]

149 [20, 331]

218 [103, 475]

0.001

Any FEIA

40/91 (44%)

16/29 (55%)

11/15 (73%)

17/20 (85%)

0.003

Aero FEIA

38/91 (42%)

16/29 (55%)

11/15 (73%)

17/20 (85%)

0.002

Perennial aero FEIA

34/91 (37%)

15/29 (52%)

11/15 (73%)

16/20 (80%)

0.001

Seasonal aero FEIA

23/91 (25%)

7/29 (24%)

4/15 (27%)

9/20 (45%)

0.33

  1. FEV1 Forced Expiratory Volume at 1 second, FEV1%pred FEV1 percent predicted, FVC forced vital capacity, FVC%pred, FVC percent predicted; FEV0.5, Forced Expiratory Volume at 0.5 second, FEF25-75, Forced expiratory flow at 25% to 75% of FVC; PEF, peak expiratory flow rate; Aero FEIA, aeroallergen fluoroenzyme immunoassay.