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Table 1 Patient characteristics of cow's milk allergic (CMA) children, diagnosed by food challenge (Challenge) or a convincing history of present milk allergy (History), and non-CMA children sensitized to milk.

From: The usefulness of casein-specific IgE and IgG4 antibodies in cow's milk allergic children

  CMA (n = 61) non-CMA (n = 22)
  Challenge History Tolerant Negative
Sex (boys/girls) 21/13 18/9 7/4 9/2
Age, years (median, range) 3.9 (1.0-12.7) 3.0 (0.8-12.8) 2.5 (1.0-15.8) 3.2 (1.4-14.2)
Serology (median, range)     
   Total IgE (kU/L) 395 (32.0-12,784) 536 (34.0-14,283) 267 (44.0-3,260) 958 (66.1-27,815)
   Milk-sIgE (kUA/L) 11.6 (< 0.35- > 100) 15.9 (1.4- > 100) 4.2 (< 0.35-27.6) 3.9 (1.0-17.3)
   Casein-sIgE (kUA/L) 13.0 (< 0.35- > 100) 21.6 (0.42- > 100) 2.3 (< 0.35-6.6) 2.0 (1.1-4.2)
Allergic symptoms, no (%)     
   Atopic dermatitis 28 (82%) 24 (89%) 9 (82%) 10 (91%)
   Asthma 9 (26%) 12 (44%) 5 (45%) 1 (9%)
   Egg allergy 25 (74%) 20 (74%) 4 (36%) 6 (54%)
Medication, no (%)     
   H1-antagonist 6 (18%) 6 (22%) 3 (27%) 3 (27%)
   Inhaled corticosteroids 2 (6%) 5 (18%) - -
  1. The latter group consisted of a subgroup of children that had obtained tolerance after a previous diagnosis of milk allergy (Tolerant) and subgroup of children that never had had a milk allergy diagnosis (Negative).
  2. For details see method section.